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never, NEVER, it will decompose, break down and eat the inside of your aluminum or pot metal real body, on steel it can attract condensation and salt water and cause rusting. Spinning reels have lots of moving parts, I like the old Conolon Silicote Grease and oil and use it exclusively and have for nearly 40 years on all my big reels. Its somewhat expensive and you could use an ounce on a reel with lots of case and gear space. However its alot like Bulldogs favorite soup, it retains its flexability forever, temperatures between minus 70 degrees and plus 200 degrees dont effect its consistancy much, its stable and at around $10 an ounce very cost effective.
Now Im gonna worry you some, depending on if its salt water use or fresh water and the degree of use. The reels I use alot, especially Salt Water are completely taken apart and cleaned and relubricated at the end of each season. Same holds true with the line on the spools, they are stripped, put on a 3 inch PVC pipe with lots of holes drilled through, washed in warm soapy dishwater, rinsed and let dry before respooling just before fishing season. The spools are cleaned carefully and waxed with a good automotive natural wax (Carnuba it breaths not Silicone based which doesnt) Ive been fishing some of the same and some really big salt water spinning reels like the Mitchell 498 for nearly 30 years and the reels are perfect and I have the pictures to prove it. On those big guys Im fishing 50# power pro braided, and some of those tuna go 100 pounds, so they are not lightly used outfits.
Same holds true for some my medium sized outfits, I like the smaller 396 pum european model reels and using the same Power Pro but now 20# for salmon, steelhead and strippers. In the semi small stuff I use the 406 Pum with again power pro 20# just a smaller spool capacity. I also use Cajun Red for my slighty lighter leader line (20-30ft) it streaches and you can avoid shock breaks at the take because the power pro doesn't streach. On teethy fish I use shorter 18Inch to 36 inch clear coated wire leaders and dont worry about the streach.
However in all cases my 408s through my 498s all are lubricated and cleaned in exactly the same way.
Richard

Toms got it right too,I use the hot sauce grease and oil on my fly reels exclusively, but they dont take much either, however the Garcia Silicote is similiar and designed for the same fishing reel applications, its not real cheap at $10 an ounce but its a bit cheaper than the hot sauce,thats why I use it on my high grease capacity spinning reels. The Hot Sauce is great by the way on big Conventional reels, they dont take alot of grease or oil like the big open cased and muti gear setups of the big spinning outfits.
Richard